Actaplanin

Actaplanin is a complex of broad-spectrum antibiotics made by Actinoplanes bacteria.^[1][2] Research carried out by a group in Eli Lilly and Co. in 1984 identified several actaplanins using high-performance liquid chromatography.^[3][4] [5] Actaplanins A, B₁, B₂, B₃, C₁ and G were shown to be composed of the same peptide core, an amino sugar, and varying amounts of glucose, mannose, andrhamnose.^[6]

See also[edit]

• Ristocetin (contains the same amino sugar as in actaplanin)

References[edit]

1. Jump up^ DEBONO, MANUEL; MERKEL, KURT E.; MOLLOY, R. MICHAEL; BARNHART, MITCHELL; PRESTI, EUGENE; HUNT, ANN H.; HAMILL, ROBERT L. (1984). "Actaplanin, new glycopeptide antibiotics produced by Actinoplanes missouriensis. The isolation and preliminary chemical characterization of actaplanin.". The Journal of Antibiotics 37 (2): 85–95. doi:10.7164/antibiotics.37.85.
2. Jump up^ Huber, Floyd M.; Pieper, Richard L.; Tietz, Anthony J. (January 1987). "Characterization of the process for the biosynthesis of the actaplanin complex by Actinoplanes missouriensis". Journal of Fermentation Technology 65 (1): 85–89. doi:10.1016/0385-6380(87)90069-0.
3. Jump up^ Debono, Manuel; Merkel, Kurt E.; Molloy, R. Michael; Barnhart, Mitchell; Presti, Eugene; Hunt, Ann H.; Hamill, Robert L. (1984)."Actaplanin, new glycopeptide antibiotics produced by Actinoplanes missouriensis. The isolation and preliminary chemical characterization of actaplanin.". The Journal of Antibiotics 37 (2): 85–95. doi:10.7164/antibiotics.37.85. Retrieved 25 December 2014.
4. Jump up^ US 4115552, Robert L Hamill & Donald C Delong, "Factor A and B of antibiotic A-4696", published 19 Sep 1978, assigned to Eli Lilly And Company
5. Jump up^ US 4322406, Manuel Debono; Robert E. Weeks & Herald J. Cole, "Antibiotic A-4696 factors B1, B2, B3, C1a, C3 and E1", published 30 Mar 1982, assigned to Eli Lilly And Company
6. Jump up^ Hunt, Ann H.; Elzey, Thomas K.; Merkel, Kurt E.; Debono, Manuel (February 1984). "Structures of the actaplanins". The Journal of Organic Chemistry 49 (4): 641–645.doi:10.1021/jo00178a012. Retrieved 25 December 2014.