Aceglutamide

Aceglutamide is a psychostimulant and nootropic^[1] used to improve memory and concentration.^[2] Chemically, it is the acetylderivative of the amino acid L-glutamine.

The salt aceglutamide aluminum (also known as KW-110 and Glumal) is effective in the treatment of ulcers.^[3][4][5][6]

Aceglutamide can also be used as a liquid-stable source of glutamine to prevent damage from protein energy malnutrition.^[7][8][9]

References[edit]

1. Jump up^ Merck Index, 11th Edition, 21
2. Jump up^ Macdonald, F, ed. (1997). Dictionary of pharmacological agents. p. A-00018. ISBN 978-0-412-46630-4.
3. Jump up^ Ito, M; Yokochi, E; Kobayashi, C; Suzuki, Y (1982). "Studies on defensive factors of experimental ulcers (2). Increasing action of aceglutamide aluminum on defensive factors in acetic acid ulcers of rats (author's transl)". Nihon yakurigaku zasshi. Folia pharmacologica Japonica 79 (4): 327–34. PMID 7095654.
4. Jump up^ Harada, Masatoshi; Yano, Shingo (1974). "Inhibitory effect of N-acetyl-L-glutamine aluminum complex (KW-110) and related compounds on gastric erosion and motility in stressed animals". Oyo Yakuri 8 (1): 1–6.
5. Jump up^ Varas Lorenzo, MJ; López Martínez, A; Gordillo Bernal, J; Mundet Surroca, J (1991). "Comparative study of 3 drugs (aceglutamide aluminum, zinc acexamate, and magaldrate) in the long-term maintenance treatment (1 year) of peptic ulcer". Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 80 (2): 91–4. PMID 1790087.
6. Jump up^ Tanaka, H; Shuto, K; Marumo, H (1982). "Effect of N-acetyl-L-glutamine aluminum complex (KW-110), an antiulcer agent, on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats". Japanese journal of pharmacology 32 (2): 307–13.doi:10.1254/jjp.32.307. PMID 7098147.
7. Jump up^ Lopez-Pedrosa Jose M; Manzano Manuel; Baxter Jeffrey H; Rueda Ricardo (2007). "N-acetyl-L-glutamine, a liquid-stable source of glutamine, partially prevents changes in body weight and on intestinal immunity induced by protein energy malnutrition in pigs". Digestive diseases and sciences 52 (3): 650–658. doi:10.1007/s10620-006-9500-y. PMID 17253138.
8. Jump up^ JP 10101576
9. Jump up^ US 2003099722